Family Guy
You might not be aware that Mila Kunis voices the unloved daughter Meg from Family Guy. This role has earned her some pretty sizable paychecks over the years, but they almost went to Lacey Chabert. Lacey was pursuing a degree at the time, so she passed on the role to focus on her schoolwork. Hopefully, the degree better is worth more than Kunis' $175,000 and $225,000 per episode...