Scarlett Johansson as Major
One of the most prominent casting scandals in the last decade was when the world learned Scarlett Johansson was cast as Major in a live-action remake of Ghost in the Shell, which is widely regarded as one of the greatest animes of all time. Audiences were confused and upset by the decision to cast a white woman rather than someone of Asian descent. Unsurprisingly, Ghost in the Shell bombed at the box office.