Power Puff Girls
These superpowered little girls are not to be messed with. Created in a lab by Professor Utonium, these girls are genetically made by sugar, spice, and everything nice. The sisters, named Blossom, Bubbles, and Buttercup, regularly rescue Townsville from local villains like Mojo Jojo, the Gangreen Gang, and Him. Though they have differing personalities, they are committed to justice. It debuted in 1998.