Some might not think that Seth Brundle (the man-fly) is a villain, but he technically is. He was an accidental, unwilling villain, but still the villain of the story nonetheless. He just found himself in a bit of bad luck, that's all.
The Bride in Black - Tom Fitzpatrick
How do you make a horror-bride as scary as possible? Hire an older man to play the role! Tom Fitzpatrick played the Bride in Black, a key horror icon in the Insidious franchise. The bride's backstory stems from the main character's tortured childhood when his mother would force him to dress in girl's clothing and respond to the name "Marilyn."