#4. Curtis “50 Cent” Jackson
One of the most extreme transformations is Curtis “50 cent” Jackson and his dramatic change in appearance. 50 Cent lost 54lbs for a role of a football player who is diagnosed with cancer; Normally weighing at 214, 50 Cent now weighs 160. Devoted to the role as a cancer patient 50 Cent even removed several of his tattoos. 50 Cent assures fans he will be back in shape and eating a regular diet in no time.