Anne Hathaway, Knocked Up
Although Anne Hathaway was initially cast as Alison Scott in the 2007 Judd Apatow rom-com, the film’s explicit birth scene drove her to give up the part. Apatow wrote to The New York Times saying, “Hathaway dropped out of the film because she didn’t want to allow us to use real footage of a woman giving birth to create the illusion that she is giving birth.”